Retinal development and maturation are orchestrated by a series of interacting signalling
networks that drive the morphogenetic transformation of the anterior develo** brain …

Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse
diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis …

Photoreceptor replacement by transplantation is proposed as a treatment for blindness.
Transplantation of healthy photoreceptor precursor cells into diseased murine eyes leads to …

Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent
stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited …

Irreversible blindness caused by loss of photoreceptors may be amenable to cell therapy.
We previously demonstrated retinal repair and restoration of vision through transplantation …

The mammalian retina displays no intrinsic regenerative capacities, therefore retinal
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …

Background Significant progress has been made in cell replacement therapy for neural
retinal diseases using retinal cells differentiated from human pluripotent stem cells. Low …

A variety of neurological disorders are attractive targets for stem and progenitor cell-based
therapy. Yet many conditions are not, whether by virtue of an inhospitable disease …

Despite different aetiologies, age-related macular degeneration and most inherited retinal
disorders culminate in the same final common pathway, the loss of photoreceptors. There …

Neural cell death is the main feature of all retinal degenerative disorders that lead to
blindness. Despite therapeutic advances, progression of retinal disease cannot always be …