Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …

Platinum chemotherapy remains the cornerstone of treatment for epithelial ovarian cancer
(OC) and Poly (ADP-ribose) polymerase inhibitors (PARPi) now have an established role as …

The past 15 years have seen an explosion in our understanding of how cells replicate
damaged DNA and how this can lead to mutagenesis. The Y-family DNA polymerases lie at …

Life as we know it, simply would not exist without DNA replication. All living organisms utilize
a complex machinery to duplicate their genomes and the central role in this machinery …

A complete understanding of DNA double-helical structure discovered by James Watson
and Francis Crick in 1953, unveil the importance and significance of DNA. For the last seven …

There are 15 different DNA polymerases encoded in mammalian genomes, which are
specialized for replication, repair or the tolerance of DNA damage. New evidence is …

Guanine-rich DNA sequences can fold into stable four-stranded structures called G-
quadruplexes or G4s. Research in the past decade demonstrated that G4 structures are …

The accurate propagation of histone marks during chromosomal replication is proposed to
rely on the tight coupling of replication with the recycling of parental histones to the daughter …

Cancer cells rely on the activation of telomerase or the alternative lengthening of telomeres
(ALT) pathways for telomere maintenance and survival. ALT involves homologous …

Spartan (also known as DVC1 and C1orf124) is a PCNA-interacting protein implicated in
translesion synthesis, a DNA damage tolerance process that allows the DNA replication …