Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer
(CRC) generally characterized by clinical symptoms, including malabsorption, intestinal …

Warfarin is a widely used anticoagulant with a narrow therapeutic index and large
interpatient variability in the dose required to achieve target anticoagulation. Common …

Alzheimer's disease (AD) is a public health priority for the 21st century. Risk reduction
currently revolves around lifestyle changes with much research trying to elucidate the …

This document is an update to the 2011 Clinical Pharmacogenetics Implementation
Consortium (CPIC) guideline for CYP2C9 and VKORC1 genotypes and warfarin dosing …

Objective It is not known whether patients with atrial fibrillation (AF) with ischemic stroke
despite oral anticoagulant therapy are at increased risk for further recurrent strokes or how …

Background Genetic variability among patients plays an important role in determining the
dose of warfarin that should be used when oral anticoagulation is initiated, but practical …

Periodontal diseases are initiated by bacterial species living in polymicrobial biofilms at or
below the gingival margin and progress largely as a result of the inflammation elicited by …

Individual variability in drug efficacy and drug safety is a major challenge in current clinical
practice, drug development, and drug regulation. For more than 5 decades, studies of …

Initiation of warfarin therapy using trial‐and‐error dosing is problematic. Our goal was to
develop and validate a pharmacogenetic algorithm. In the derivation cohort of 1,015 …

In 2001, the US Food and Nutrition Board concluded that there were insufficient data with
which to establish a RDA for vitamin K, in large part because of a lack of robust endpoints …