Insomnia disorder: State of the science and challenges for the future

D Riemann, F Benz, RJ Dressle… - Journal of sleep …, 2022‏ - Wiley Online Library
Insomnia disorder comprises symptoms during night and day that strongly affect quality of
life and wellbeing. Prolonged sleep latency, difficulties to maintain sleep and early morning …

[HTML][HTML] Brain mechanisms of insomnia: new perspectives on causes and consequences

EJW Van Someren - Physiological reviews, 2021‏ - journals.physiology.org
While insomnia is the second most common mental disorder, progress in our understanding
of underlying neurobiological mechanisms has been limited. The present review addresses …

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

PR Jansen, K Watanabe, S Stringer, N Skene… - Nature …, 2019‏ - nature.com
Insomnia is the second most prevalent mental disorder, with no sufficient treatment
available. Despite substantial heritability, insight into the associated genes and …

The impact of stress on sleep: pathogenic sleep reactivity as a vulnerability to insomnia and circadian disorders

DA Kalmbach, JR Anderson… - Journal of sleep …, 2018‏ - Wiley Online Library
Sleep reactivity is the trait‐like degree to which stress exposure disrupts sleep, resulting in
difficulty falling and staying asleep. Individuals with highly reactive sleep systems …

Mechanisms underlying the association between insomnia, anxiety, and depression in adolescence: implications for behavioral sleep interventions

MJ Blake, JA Trinder, NB Allen - Clinical psychology review, 2018‏ - Elsevier
There is robust evidence of an association between insomnia, anxiety, and depression in
adolescence. The aim of this review is to describe and synthesize potential mechanisms …

EEG spectral analysis in insomnia disorder: A systematic review and meta-analysis

W Zhao, EJW Van Someren, C Li, X Chen, W Gui… - Sleep medicine …, 2021‏ - Elsevier
Insomnia disorder (ID) has become the second-most common mental disorder. Despite
burgeoning evidence for increased high-frequency electroencephalography (EEG) activity …

Hyperarousal in insomnia disorder: Current evidence and potential mechanisms

RJ Dressle, D Riemann - Journal of Sleep Research, 2023‏ - Wiley Online Library
Insomnia disorder is among the most frequent mental disorders, making research on its
aetiology and pathophysiology particularly important. A unifying element of many …

Insomnia—A risk factor for mental disorders

E Hertenstein, F Benz, CL Schneider… - Journal of sleep …, 2023‏ - Wiley Online Library
Longitudinal studies observed that individuals suffering from insomnia disorder have a
higher vulnerability to develop symptoms of psychopathology compared with good sleepers …

REM sleep: an unknown indicator of sleep quality

G Barbato - International journal of environmental research and …, 2021‏ - mdpi.com
Standard polysomnographic analysis of sleep has not provided evidence of an objective
measure of sleep quality; however, factors such as sleep duration and sleep efficiency are …

[HTML][HTML] Bidirectional relationship between sleep and depression

S Yasugaki, H Okamura, A Kaneko, Y Hayashi - Neuroscience Research, 2023‏ - Elsevier
Patients with depression almost inevitably exhibit abnormalities in sleep, such as shortened
latency to enter rapid eye movement (REM) sleep and decrease in electroencephalogram …