Advances in radiotherapy for glioblastoma

J Mann, R Ramakrishna, R Magge… - Frontiers in …, 2018 - frontiersin.org
External beam radiotherapy (RT) has long played a crucial role in the treatment of
glioblastoma. Over the past several decades, significant advances in RT treatment and …

Surgical management of Glioma Grade 4: Technical update from the neuro-oncology section of the Italian Society of Neurosurgery (SINch®): A systematic review

T Ius, G Sabatino, PP Panciani, MM Fontanella… - Journal of neuro …, 2023 - Springer
Purpose The extent of resection (EOR) is an independent prognostic factor for overall
survival (OS) in adult patients with Glioma Grade 4 (GG4). The aim of the neuro-oncology …

Integrating imaging and genomic data for the discovery of distinct glioblastoma subtypes: a joint learning approach

J Guo, A Fathi Kazerooni, E Toorens, H Akbari, F Yu… - Scientific Reports, 2024 - nature.com
Glioblastoma is a highly heterogeneous disease, with variations observed at both
phenotypical and molecular levels. Personalized therapies would be facilitated by non …

Mortality trends in primary malignant brain and central nervous system tumors vary by histopathology, age, race, and sex

M Thierheimer, G Cioffi, KA Waite, C Kruchko… - Journal of Neuro …, 2023 - Springer
Purpose Primary malignant brain and other central nervous system tumors are rare cancers
that have shown rising mortality rates in recent years. To elucidate potential factors involved …

Glioblastoma in elderly patients: current management and future perspectives

G Minniti, G Lombardi, S Paolini - Cancers, 2019 - mdpi.com
The incidence of glioblastoma (GBM) in the elderly population is slowly increasing in
Western countries. Current management includes surgery, radiation therapy (RT) and …

Impact of removed tumor volume and location on patient outcome in glioblastoma

AW Awad, M Karsy, N Sanai, R Spetzler… - Journal of neuro …, 2017 - Springer
Glioblastoma is an aggressive primary brain tumor with devastatingly poor prognosis.
Multiple studies have shown the benefit of wider extent of resection (EOR) on patient overall …

Association between treatment-related lymphopenia and overall survival in elderly patients with newly diagnosed glioblastoma

JS Mendez, A Govindan, J Leong, F Gao… - Journal of neuro …, 2016 - Springer
Management of patients with glioblastoma (GBM) often includes radiation (RT) and
temozolomide (TMZ). The association between severe treatment-related lymphopenia (TRL) …

Histological and molecular glioblastoma, IDH-wildtype: a real-world landscape using the 2021 WHO classification of central nervous system tumors

X Guo, L Gu, Y Li, Z Zheng, W Chen, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Introduction Glioblastoma (GBM), the most lethal primary brain malignancy, is divided into
histological (hist-GBM) and molecular (mol-GBM) subtypes according to the 2021 World …

The interaction between TERT promoter mutation and MGMT promoter methylation on overall survival of glioma patients: a meta-analysis

HG Vuong, TQ Nguyen, TNM Ngo, HC Nguyen… - BMC cancer, 2020 - Springer
Background There are controversial results concerning the prognostic implication of TERT
promoter mutation in glioma patients concerning MGMT status. In this meta-analysis, we …

Importance and evidence of extent of resection in glioblastoma

V Wykes, A Zisakis, M Irimia, I Ughratdar… - … Surgery Part A …, 2021 - thieme-connect.com
Maximal safe resection is an essential part of the multidisciplinary care of patients with
glioblastoma. A growing body of data shows that gross total resection is an independent …