In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …

Significance: It is increasingly clear that proline metabolism plays an important role in
metabolic reprogramming, not only in cancer but also in related fields such as aging …

Some development stages of the trypanosomatid protozoan parasites are well adapted to in
vitro culture. They can be maintained in rich medium containing large excess of glucose and …

Protozoan Kinetoplastida, including the pathogenic trypanosomatids of the genera
Trypanosoma and Leishmania, compartmentalize several important metabolic systems in …

Developmental steps in the trypanosome life-cycle involve transition between replicative
and non-replicative forms specialised for survival in, and transmission between, mammalian …

Cellular metabolic activity is a highly complex, dynamic, regulated process that is influenced
by numerous factors, including extracellular environmental signals, nutrient availability and …

Adaptation to different nutritional environments is essential for life cycle completion by all
Trypanosoma brucei sub-species. In the tsetse fly vector, L-proline is among the most …

Metabolomics coupled with heavy-atom isotope-labelled glucose has been used to probe
the metabolic pathways active in cultured bloodstream form trypomastigotes of …

The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …

Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus
Leishmania, form a group of flagellated protists that threaten human health. These …