Umpolung strategies, defined as synthetic approaches which reverse commonly accepted
reactivity patterns, are broadly recognized as enabling tools for small molecule synthesis …

A metal-free method for the vicinal thiosulfonylation of unactivated alkenes with
thiosulfonates using 9-mesityl-10-methylacridinium perchlorate as the photo-organocatalyst …

The construction of amide bonds and peptide linkages is one of the most fundamental
transformations in all life processes and organic synthesis. The synthesis of structurally …

The simultaneous binding/dissociation of multiple bonds in a one-pot manner by
multicomponent reactions provide an important approach for develo** novel and …

A series of novel α-ketoamide derivatives bearing a vanillin skeleton were designed and
synthesized. Bioactivity tests on virus and bacteria were performed. The results indicated …

A catalytic enantioselective three-component Ugi reaction was developed. SPINOL-derived
phosphoric acid with bulky 2, 4, 6-tricyclohexylphenyl groups at the 6, 6′ positions was …

A new bio-inspired approach is reported for amide and peptide synthesis using α-amino
esters that possess a potential activating group (PAG) at the ester residue. To activate the …

We have successfully developed an efficient method for synthesizing secondary amides
utilizing easily accessible N-(2-aminophenyl) benzamide and phenyl isocyanate. Notably …

The physicochemical properties (pKa (H), log P, and aqueous solubility) of fluoroalkyl‐
substituted heterocyclic amines were profiled to facilitate the amines' rational application in …

A chemoselective and catalytic transamidation for peptide synthesis is described.
Transamidation under Zn catalysis is chemoselectively achieved by amino acid …