Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …

Kidney stones (also known as urinary stones or nephrolithiasis) are highly prevalent,
affecting approximately 10% of adults worldwide, and the incidence of stone disease is …

Intestinal epithelial expression of the tight junction protein claudin-2, which forms
paracellular cation and water channels, is precisely regulated during development and in …

Kidney stone disease (KSD) is one of the earliest medical diseases known, but the
mechanism of its formation and metabolic changes remain unclear. The formation of kidney …

Sequential expression of claudins, a family of tight junction proteins, along the nephron
mirrors the sequential expression of ion channels and transporters. Only by the interplay of …

Calcium (Ca2+) homeostasis is maintained through coordination between intestinal
absorption, renal reabsorption, and bone remodeling. Intestinal and renal (re) absorption …

GeoBioMed—a new transdisciplinary approach that integrates the fields of geology, biology
and medicine—reveals that kidney stones composed of calcium-rich minerals precipitate …

The kidney plays a pivotal role in regulating calcium levels within the body. Approximately
98% of the filtered calcium is reabsorbed in the nephron, and this process is tightly …

Central to the maintenance of calcium homeostasis is the regulated reabsorption of calcium
along the nephron. To this end, parathyroid hormone (PTH) is released from the parathyroid …

Nephrolithiasis is a worldwide problem with increasing prevalence, enormous costs, and
significant morbidity. Calcium-containing kidney stones are by far the most common kidney …