Abstract Type 2 diabetes (T2DM) results when increases in beta cell function and/or mass
cannot compensate for rising insulin resistance. Numerous studies have documented the …

The consensus model of stimulus–secretion coupling in beta cells attributes glucose-
induced insulin secretion to a sequence of events involving acceleration of metabolism …

Summary Protein-restricted (PR), high-carbohydrate diets improve metabolic health in
rodents, yet the precise dietary components that are responsible for these effects have not …

Pancreatic beta (β) cell dysfunction results in compromised insulin release and, thus, failed
regulation of blood glucose levels. This forms the backbone of the development of diabetes …

Mathematical models of biological systems often have components that vary on different
timescales. This multi-timescale character can lead to problems when doing computer …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

The pancreatic islet is a highly coupled, multicellular system that exhibits complex
spatiotemporal electrical activity in response to elevated glucose levels. The emergent …

Functional pancreatic islet beta cells are essential to ensure glucose homeostasis across
species from zebrafish to humans. These cells show significant heterogeneity, and emerging …

Glucose homeostasis is critically dependent on insulin release from pancreatic β-cells,
which is strictly regulated by glucose-induced oscillations in membrane potential (Vm) and …

Beta cells of the pancreatic islet express many different types of ion channels. These
channels reside in the β-cell plasma membrane as well as subcellular organelles and their …