Uncovering the complex role of interferon-gamma in suppressing type 2 immunity to cancer

AA Bhat, A Goyal, R Thapa, I Kazmi, SI Alzarea… - Cytokine, 2023 - Elsevier
Cancer involves cells' abnormal growth and ability to invade or metastasize to different body
parts. Cancerous cells can divide uncontrollably and spread to other areas through the …

From LncRNA to metastasis: The MALAT1-EMT axis in cancer progression

R Thapa, O Afzal, M Afzal, G Gupta, AA Bhat… - … -Research and Practice, 2024 - Elsevier
Cancer is a complex disease that causes abnormal genetic changes and unchecked cellular
growth. It also causes a disruption in the normal regulatory processes that leads to the …

A comprehensive review on the emerging role of long non-coding RNAs in the regulation of NF-κB signaling in inflammatory lung diseases

AA Bhat, O Afzal, N Agrawal, R Thapa… - International journal of …, 2023 - Elsevier
Public health globally faces significant risks from conditions like acute respiratory distress
syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and various …

Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: from mechanisms to therapeutics

R Thapa, M Afzal, A Goyal, G Gupta, AA Bhat… - Life sciences, 2024 - Elsevier
Glioblastoma (GBM) is the most prevalent and deadly primary brain tumor type, with a
discouragingly low survival rate and few effective treatments. An important function of the …

[HTML][HTML] CircRNAs: Pivotal modulators of TGF-β signalling in cancer pathogenesis

AA Bhat, G Gupta, R Dahiya, R Thapa, A Gahtori… - Non-coding RNA …, 2024 - Elsevier
The intricate molecular landscape of cancer pathogenesis continues to captivate
researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the …

ncRNAs and their impact on dopaminergic neurons: autophagy pathways in Parkinson's disease

R Thapa, E Moglad, M Afzal, G Gupta, AA Bhat… - Ageing Research …, 2024 - Elsevier
Parkinson's Disease (PD) is a complex neurological illness that causes severe motor and
non-motor symptoms due to a gradual loss of dopaminergic neurons in the substantia nigra …

Autophagy‐associated non‐coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis

MS Hussain, E Moglad, M Afzal… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Parkinson's disease (PD) is a degenerative neurological condition marked by
the gradual loss of dopaminergic neurons in the substantia nigra pars compacta. The …

Probing the links: long non-coding RNAs and NF-κB signalling in atherosclerosis

MS Hussain, O Afzal, G Gupta, ASA Altamimi… - … -Research and Practice, 2023 - Elsevier
Atherosclerosis is a chronic inflammatory disease that involves the accumulation of lipids
and immune cells in the arterial wall. NF-kB signaling is a key regulator of inflammation and …

Exploring the oncogenic and tumor-suppressive roles of Circ-ADAM9 in cancer

MS Hussain, E Moglad, P Bansal, H Kaur… - … -Research and Practice, 2024 - Elsevier
Circular RNAs (circRNAs) constitute a recently identified category of closed continuous loop
RNA transcripts, serving as a subset of competing endogenous RNAs (ceRNAs) with the …

The role of sirtuin 1 in ageing and neurodegenerative disease: a molecular perspective

R Thapa, E Moglad, M Afzal, G Kumar, AA Bhat… - Ageing Research …, 2024 - Elsevier
Abstract Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, has emerged as a key
regulator of cellular processes linked to ageing and neurodegeneration. SIRT1 modulates …