The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …

While the tumor suppressor functions of p53 have long been recognized, the contribution of
p53 to numerous other aspects of disease and normal life is only now being appreciated …

Abstract p53 is a transcription factor that suppresses tumor growth through regulation of
dozens of target genes with diverse biological functions. The activity of this master …

Enhancer-binding pluripotency regulators (Sox2 and Oct4) play a seminal role in embryonic
stem (ES) cell-specific gene regulation. Here, we combine in vivo and in vitro single …

Inactivation of p53 is critical for the formation of most tumors. Illumination of the key function
(s) of p53 protein in protecting cells from becoming cancerous is therefore a worthy goal …

Gene expression originates from individual DNA molecules within living cells. Like many
single-molecule processes, gene expression and regulation are stochastic, that is, sporadic …

A number of vital biological processes rely on fast and precise recognition of a specific DNA
sequence (site) by a protein. How can a protein find its site on a long DNA molecule among …

It is known that DNA-binding proteins can slide along the DNA helix while searching for
specific binding sites, but their path of motion remains obscure. Do these proteins undergo …

DNA crosslinks block DNA replication and are repaired by the Fanconi anaemia pathway.
The FANCD2–FANCI (D2–I) protein complex is central to this process as it initiates repair by …

Early in vivo studies demonstrated the involvement of a tumor-suppressing transcription
factor, p53, into cellular droplets such as Cajal and promyelocytic leukemia protein bodies …