Femtosecond crystallography with ultrabright electrons and x-rays: Capturing chemistry in action

RJD Miller - Science, 2014 - science.org
With the recent advances in ultrabright electron and x-ray sources, it is now possible to
extend crystallography to the femtosecond time domain to literally light up atomic motions …

Capturing chemistry in action with electrons: realization of atomically resolved reaction dynamics

AA Ischenko, PM Weber, RJD Miller - Chemical reviews, 2017 - ACS Publications
One of the grand challenges in chemistry has been to directly observe atomic motions
during chemical processes. The depiction of the nuclear configurations in space-time to …

Direct observation of ultrafast collective motions in CO myoglobin upon ligand dissociation

TRM Barends, L Foucar, A Ardevol, K Nass, A Aquila… - Science, 2015 - science.org
The hemoprotein myoglobin is a model system for the study of protein dynamics. We used
time-resolved serial femtosecond crystallography at an x-ray free-electron laser to resolve …

Terahertz underdamped vibrational motion governs protein-ligand binding in solution

DA Turton, HM Senn, T Harwood, AJ Lapthorn… - Nature …, 2014 - nature.com
Low-frequency collective vibrational modes in proteins have been proposed as being
responsible for efficiently directing biochemical reactions and biological energy transport …

Femtosecond electron diffraction:'making the molecular movie'

JR Dwyer, CT Hebeisen… - … of the Royal …, 2006 - royalsocietypublishing.org
Femtosecond electron diffraction (FED) has the potential to directly observe transition state
processes. The relevant motions for this barrier-crossing event occur on the hundred …

Map** atomic motions with ultrabright electrons: The chemists' Gedanken experiment enters the lab frame

RJD Miller - Annual review of physical chemistry, 2014 - annualreviews.org
This review documents the development of high–bunch charge electron pulses with
sufficient combined spatiotemporal resolution and intensity to literally light up atomic …

High-precision megahertz-to-terahertz dielectric spectroscopy of protein collective motions and hydration dynamics

A Charkhesht, CK Regmi… - The Journal of …, 2018 - ACS Publications
The low-frequency collective vibrational modes in proteins as well as the protein–water
interface have been suggested as dominant factors controlling the efficiency of biochemical …

Femtosecond electron diffraction studies of strongly driven structural phase transitions

BJ Siwick, JR Dwyer, RE Jordan, RJD Miller - Chemical Physics, 2004 - Elsevier
The new technique of femtosecond electron diffraction is applied to the study of a strongly
driven, laser induced solid-to-liquid phase transition in polycrystalline aluminum. This …

[책][B] Proteins: energy, heat and signal flow

DM Leitner, JE Straub - 2009 - taylorfrancis.com
Computational modeling can provide a wealth of insight into how energy flow in proteins
mediates protein function. Computational methods can also address fundamental questions …

Making the molecular movie': first frames

RJD Miller, R Ernstorfer, M Harb, M Gao… - … A: Foundations of …, 2010 - scripts.iucr.org
Recent advances in high-intensity electron and X-ray pulsed sources now make it possible
to directly observe atomic motions as they occur in barrier-crossing processes. These rare …