This review reports in detail the cellular and molecular mechanisms which regulate the bone
remodeling process in relation to oxidative stress (OS), inflammatory factors, and estrogen …

Bone is a dynamic tissue constantly responding to environmental changes such as
nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone …

Rheumatoid arthritis (RA) is an inflammatory disease characterized by a variety of symptoms
and pathologies often presenting with polyarthritis. The primary symptom in the initial stage …

Vascular calcification (VC) is regarded as an important pathological change lacking effective
treatment and associated with high mortality. Sirtuin 6 (SIRT6) is a member of the Sirtuin …

Bone-related diseases are major contributors to morbidity and mortality in elderly people
and the current treatments result in insufficient healing and several complications. One of the …

Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a
leading cause of cancer deaths worldwide. Chemotherapy as monotherapy can lead to …

Mesenchymal stromal/stem cells (MSCs) are multipotent stem cells present in most fetal and
adult tissues. Ex vivo culture‐expanded MSCs are being investigated for tissue repair and …

Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …

Mesenchymal stem cells (MSCs) are characterized to have the capacity of self-renewal and
the potential to differentiate into mesoderm, ectoderm-like and endoderm-like cells. MSCs …

Background/aim Autophagy is a macromolecular degradation process playing a pivotal role
in the maintenance of stem-like features and in the morpho-functional remodeling of the …