This white paper discusses prospects for advancing hyperpolarization technology to better
understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13 C …

Hyperpolarized (HP) carbon 13 (13C) MRI is an emerging molecular imaging method that
allows rapid, noninvasive, and pathway-specific investigation of dynamic metabolic and …

Alternative modes of metabolism enable cells to resist metabolic stress. Inhibiting these
compensatory pathways may produce synthetic lethality. We previously demonstrated that …

A detailed knowledge of the complex processes that make cells and organisms alive is
fundamental in order to understand diseases and to develop novel drugs and therapeutic …

The study of transient chemical phenomena by conventional NMR has proved elusive,
particularly for non-1H nuclei. For 13C, hyperpolarization using the dynamic nuclear …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

KRAS mutation, which occurs in∼ 95% of pancreatic ductal adenocarcinoma (PDA), has
been shown to program tumor metabolism. MCT4 is highly upregulated in a subset of PDA …

Applications of NMR for metabolomics and metabolic profiling continue to grow rapidly as
does the refinement of methods for the measurement, analysis, and interpretation of …

This review focuses on MRI contrast agents that are responsive to a change in a
physiological biomarker. The response mechanisms are dependent on six physicochemical …

Non-invasive 13C magnetic resonance spectroscopy measurements of the uptake and
subsequent metabolism of 13C-labeled substrates is a powerful method for studying …