Cytochrome P450 proteins comprise a large family of enzymes that utilize a heme cofactor to
perform a diverse array of chemical transformations during secondary metabolite …

P450 NascB catalyzes the coupling of cyclo-(l-tryptophan-l-proline)(1) to generate (−)-
naseseazine C (2) through intramolecular C–N bond formation and intermolecular C–C …

Paclitaxel is a famous chemotherapeutic agent, but its microbial production poses a long-
standing challenge due to its poor product selectivity. Taxadiene-5α-hydroxylase …

The cytochrome P450 (CYP) AspB is involved in the biosynthesis of the diketopiperazine
(DKP) aspergilazine A. Tryptophan-linked dimeric DKP alkaloids are a large family of natural …

Abstract The 2, 5-diketopiperazines are a prominent class of bioactive molecules. The
nocardioazines are actinomycete natural products that feature a pyrroloindoline …

Peptide side chain cross-linking is an important feature of many natural products, with an
increasing number of examples catalyzed by cytochrome P450s being reported from …

Cytochrome P450s belong to a family of heme‐binding monooxygenases, which catalyze
regio‐and stereospecific functionalisation of C–H, C–C, and C–N bonds, including …

Selective C (sp 3)–H bond activation and functionalization into a C–N bond has been one of
the major challenges facing the pharmaceutical and fine chemical industries. Being the …

Dimeric indole‐containing diketopiperazines (di‐DKPs) are a diverse group of natural
products produced through cytochrome P450‐catalyzed C–C or C–N coupling reactions …

The properties of natural products can be significantly influenced by glycosylation,
emphasizing the key role of glycosyltransferases (GTs) in this process. The pursuit of …