Histone deacetylases (HDACs) and histone acetyl transferases (HATs) are two
counteracting enzyme families whose enzymatic activity controls the acetylation state of …

Histone acetylation and deacetylation in the yeast Saccharomyces cerevisiae occur by
targeting acetyltransferase and deacetylase enzymes to gene promoters and, in an …

Histone deacetylase enzymes (HDACs) are emerging cancer drug targets. They regulate
gene expression by removing acetyl groups from lysine residues in histone tails, resulting in …

Yeast Rpd3 histone deacetylase plays an important role at actively transcribed genes. We
characterized two distinct Rpd3 complexes, Rpd3L and Rpd3S, by MudPIT analysis. Both …

Abstract Histone deacetylases (HDACs) 1, 2 and 3 form the catalytic subunit of several large
transcriptional repression complexes. Unexpectedly, the enzymatic activity of HDACs in …

The yeast histone deacetylase Rpd3 can be recruited to promoters to repress transcription
initiation. Biochemical, genetic, and gene-expression analyses show that Rpd3 exists in two …

Repression of gene transcription is linked to regulation of chromatin structure through
deacetylation of core histone amino-terminal tails. This action is mediated by histone …

Deletions of three yeast genes, SET2, CDC73, and DST1, involved in transcriptional
elongation and/or chromatin metabolism were used in conjunction with genetic array …

Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from
lysine residues in both histone and non‐histone proteins. They play a key role in the …

SIN3 was first identified genetically as a global regulator of transcription. Sin3 is a large
protein composed mainly of protein-interaction domains, whose function is to provide …