Acetylaminofluorene and 2-aminofluorene are among the most intensively studied of all
chemical mutagens and carcinogens. Fundamental research findings concerning the …

Carcinogens are generally mutagens, which is understandable given that tumor cells grow
uncontrollably because they have mutations in critical genes involved in growth control …

A method was developed to clone, without the use of specific functional assays,
complementary DNAs (cDNAs) that carry specific amino-terminal signal sequences, such as …

Most organisms contain several members of a recently discovered class of DNA
polymerases (umuC/dinB superfamily) potentially involved in replication of damaged DNA …

We have constructed a gapped plasmid vector in which a single defined lesion is
introduced, site-specifically, within a single-strand region. Efficiency of translesional …

Exposure of Escherichia coli to UV light increases expression of NrdAB, the major
ribonucleotide reductase leading to a moderate increase in dNTP levels. The role of …

This perspective explores mechanisms of frameshift mutagenesis as revealed by studies of
selected aromatic amines and amides. The data are drawn primarily from studies of three …

The genome and its nucleotide precursor pool are under sustained attack by radiation,
reactive oxygen and nitrogen species, chemical carcinogens, hydrolytic reactions, and …

Рост онкологических заболеваний в текущем столетии происходил такими быстрыми
темпами, что это дало основание для сравнения его с эпидемией. Обширные …

Cells contain specialized DNA polymerases that are able to copy past lesions with an
associated risk of generating mutations, the major cause of cancer. Here, we reconstitute …