Chromosome territories (CTs) constitute a major feature of nuclear architecture. In a brief
statement, the possible contribution of nuclear architecture studies to the field of …

Over the past few years it has become evident that the intermediate filament proteins, the
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but …

We show that the nuclear architecture of rod photoreceptor cells differs fundamentally in
nocturnal and diurnal mammals. The rods of diurnal retinas possess the conventional …

In vivo, the human genome functions as a complex, folded, three-dimensional chromatin
polymer. Understanding how the human genome is spatially organized and folded inside …

In humans, nearly two meters of genomic material must be folded to fit inside each
micrometer-scale cell nucleus while remaining accessible for gene transcription, DNA …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Recent methodological advancements in microscopy and DNA sequencing-based methods
provide unprecedented new insights into the spatio-temporal relationships between …

Although important for gene regulation, most studies of genome organization use either
fluorescence in situ hybridization (FISH) or chromosome conformation capture (3C) …

Nearly 7 decades have elapsed since Francis Crick introduced the central dogma of
molecular biology, as part of his ideas on protein synthesis, setting the fundamental rules of …

Genome-wide molecular studies have provided new insights into the organization of nuclear
chromatin by revealing the presence of chromatin domains of differing transcriptional …