Boosting pathogen genomics and bioinformatics workforce in Africa

H Onywera, P Ondoa, F Nfii, A Ogwell… - The Lancet Infectious …, 2024 - thelancet.com
Next-generation sequencing (NGS) of genomic data has established its fundamental value
in public health surveillance, research and development, and precision medicine. In Africa …

Metagenomic pathogen sequencing in resource-scarce settings: lessons learned and the road ahead

C Yek, AR Pacheco, M Vanaerschot, JA Bohl… - Frontiers in …, 2022 - frontiersin.org
Metagenomic next-generation sequencing (mNGS) is the process of sequencing all genetic
material in a biological sample. The technique is growing in popularity with myriad …

Integrating scalable genome sequencing into microbiology laboratories for routine antimicrobial resistance surveillance

M Kekre, SA Arevalo, MF Valencia… - Clinical Infectious …, 2021 - academic.oup.com
Antimicrobial resistance (AMR) is considered a global threat, and novel drug discovery
needs to be complemented with systematic and standardized epidemiological surveillance …

Overcoming data bottlenecks in genomic pathogen surveillance

AO Afolayan, JF Bernal, JM Gayeta… - Clinical Infectious …, 2021 - academic.oup.com
Performing whole genome sequencing (WGS) for the surveillance of antimicrobial
resistance offers the ability to determine not only the antimicrobials to which rates of …

Technological Barriers to Routine Genomic Surveillance for Vaccine Development Against SARS‐CoV‐2 in Africa: A Systematic Review

KCC Konono, K Msusa, S M**anjira… - Influenza and Other …, 2024 - Wiley Online Library
ABSTRACT The Global Initiative on Sharing All Influenza Data, a public‐access database
for sharing severe acute respiratory syndrome coronavirus 2 genomic sequencing data, has …

Health system interventions and responses to anti-microbial resistance: A sco** review of evidence from 15 African countries

JAK Alhassan, CK Abdallah - PLOS Global Public Health, 2024 - journals.plos.org
The global rise in antimicrobial resistance (AMR) is claiming the lives of more than 1.2
million people each year. According to the World Health Organization (WHO) this global …

Establishing human microbial observatory programs in low‐and middle‐income countries

JI Gordon, MJ Barratt, MC Hibberd… - Annals of the New …, 2024 - Wiley Online Library
Studies of the human microbiome are progressing rapidly but have largely focused on
populations living in high‐income countries. With increasing evidence that the microbiome …

A One Health approach to fight antimicrobial resistance in Uganda: implementation experience, results, and lessons learned

R Kiggundu, JP Waswa, N Konduri, H Kasujja… - Biosafety and …, 2024 - Elsevier
Uganda has been implementing the Global Health Security Agenda (GHSA) since 2015 to
build its capacity according to World Health Organization (WHO) Benchmarks on …

Implementing Whole-Genome Sequencing for Ongoing Surveillance of Antimicrobial Resistance: Exemplifying Insights Into Klebsiella pneumoniae

DM Aanensen, CC Carlos… - Clinical Infectious …, 2021 - academic.oup.com
In this Supplement, we detail outputs of the National Institute for Health Research Global
Health Research Unit on Genomic Surveillance of Antimicrobial Resistance project …