Heparan sulfate proteoglycans (HSPGs) are primary components at the interface between
virtually every eukaryotic cell and its extracellular matrix. HSPGs not only provide a storage …

Background & Aims: Chronic inflammation is a risk factor for colon cancer in patients with
ulcerative colitis (UC). The molecular mechanisms linking inflammation and colon …

Background & Aims: We recently showed that mice deficient in Toll-like receptor 4 (TLR4) or
its adapter molecule MyD88 have increased signs of colitis compared with wild-type (WT) …

Ulcerative colitis is a nonspecific inflammatory disorder characterized by oxidative and
nitrosative stress, leucocyte infiltration and upregulation of inflammatory mediators …

Glutathione transferase (GST) isoezymes are encoded by three separate families of genes
(designated cytosolic, microsomal and mitochondrial transferases), with distinct evolutionary …

Previous studies have reported the anti-inflammatory properties of pomegranate extracts,
suggesting that ellagitannins (ET) and ellagic acid (EA) are the main anti-inflammatory …

Enterocytes regulate gut maintenance and defence by secreting and responding to
inflammatory mediators and by modulating the intestinal epithelial permeability. In order to …

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is closely associated
with colon cancer. Expression of the enzyme heparanase is clearly linked to colon …

The mechanisms by which IL-6 contributes to the pathogenesis of chronic inflammatory
diseases and cancer are not fully understood. We previously reported that cyclooxygenase …

Arachidonic acid (AA) and its metabolites have recently generated a heightened interest due
to growing evidence of their significant role in cancer biology. Thus, inhibitors of the AA …