Objective The goal of this narrative review is to provide an overview of migraine
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …

Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …

Scientific evidence supports the notion that migraine pathophysiology involves inherited
alteration of brain excitability, intracranial arterial dilatation, recurrent activation, and …

Migraine is a collection of perplexing neurological conditions in which the brain and its
associated tissues have been implicated as major players during an attack. Once …

Chronic pain is a major challenge to clinical practice and basic science. The peripheral and
central neural networks that mediate nociception show extensive plasticity in pathological …

A Systems Neuroscience Approach to Migraine: Neuron Skip to Main Content Skip to Main
Menu Advertisement Neuron This journal offers authors two options (open access or …

Migraine is a common and complex brain disorder. Although it is clear that head pain is a
key manifestation of the disorder for most patients, what drives the activation of neuronal …

Migraine is a complex neurovascular pain disorder linked to the meninges, a border tissue
innervated by neuropeptide-containing primary afferent fibers chiefly from the trigeminal …

Animal models have provided a growing body of information about the pathophysiology of
headaches and novel therapeutic targets. In recent years, experiments in awake animals …