Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …

Alzheimer's disease (AD) is characterized by dysfunctional intracellular and extracellular
biochemical processes that result in neuron death. This article summarizes hypotheses …

The multifunctional nature of Alzheimer's disease calls for MTDLs (multitarget-directed
ligands) to act on different components of the pathology, like the cholinergic dysfunction and …

By using fragments endowed with interesting and complementary properties for the
treatment of Alzheimer's disease (AD), a new family of tacrine–4-oxo-4 H-chromene hybrids …

Tacrine and PBT2 (an 8-hydroxyquinoline derivative) are well-known drugs that inhibit
cholinesterases and decrease β-amyloid (Aβ) levels by complexation of redox-active metals …

A series of novel tacrine-coumarin hybrids were designed, synthesized and evaluated as
multi-target agents against Alzheimer's disease. The biological assays indicated that most of …

Tacrine and melatonin are well-known drugs with activities as an acetylcholinesterase
(AChE) inhibitor and free radical scavenger, respectively. In this work, we report new hybrids …

The therapeutic arsenal for the treatment of Alzheimer s disease (AD) remains confined to a
group of four inhibitors of AChE and one NMDA receptor antagonist, which are used to …

Neurodegenerative disorders, such as Alzheimer's disease, are often characterised by the
degeneration of the cholinergic system. Thus, the aim of many treatment regimens is to …

Twenty-six new tacrine–benzofuran hybrids were designed, synthesized, and evaluated in
vitro on key molecular targets for Alzheimer's disease. Most hybrids exhibited good inhibitory …