Electrospun fiber‐based immune engineering in regenerative medicine

Y Xu, Q Saiding, X Zhou, J Wang, W Cui… - Smart Medicine, 2024 - Wiley Online Library
Immune engineering, a burgeoning field within regenerative medicine, involves a spectrum
of strategies to optimize the intricate interplay between tissue regenerative biomaterials and …

Neutrophil extracellular traps in homeostasis and disease

H Wang, SJ Kim, Y Lei, S Wang, H Wang… - … and Targeted Therapy, 2024 - nature.com
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are
renowned for their propensity to expel decondensed chromatin embedded with inflammatory …

Electrospun fiber-based strategies for controlling early innate immune cell responses: towards immunomodulatory mesh designs that facilitate robust tissue repair

D Venugopal, S Vishwakarma, I Kaur, S Samavedi - Acta Biomaterialia, 2023 - Elsevier
Electrospun fibrous meshes are widely used for tissue repair due to their ability to guide a
host of cell responses including phenotypic differentiation and tissue maturation. A critical …

Neutrophils in biomaterial-guided tissue regeneration: matrix reprogramming for angiogenesis

AE Fetz, MZ Radic, GL Bowlin - Tissue Engineering Part B: Reviews, 2021 - liebertpub.com
Biomaterial-guided in situ tissue regeneration uses biomaterials to stimulate and guide the
body's endogenous, regenerative processes to drive functional tissue repair and …

Neutrophil extracellular traps: inflammation and biomaterial preconditioning for tissue engineering

AE Fetz, GL Bowlin - Tissue Engineering Part B: Reviews, 2022 - liebertpub.com
Tissue injury initiates a tissue repair program, characterized by acute inflammation and
recruitment of immune cells, dominated by neutrophils. Neutrophils prevent infection in the …

Human neutrophil FcγRIIIb regulates neutrophil extracellular trap release in response to electrospun polydioxanone biomaterials

AE Fetz, MZ Radic, GL Bowlin - Acta biomaterialia, 2021 - Elsevier
During the acute inflammatory response, the release of neutrophil extracellular traps (NETs)
is a pro-inflammatory, preconditioning event on a biomaterial surface. Therefore, regulation …

Mechanical characterization and neutrophil NETs response of a novel hybrid geometry polydioxanone near-field electrospun scaffold

WE King, GL Bowlin - Biomedical Materials, 2021 - iopscience.iop.org
Near-field electrospinning (NFES) is a direct fiber writing sub-technique derived from
traditional electrospinning (TES) by reducing the air gap distance to the magnitude of …

Controlled delivery of pan-PAD-inhibitor Cl-amidine using poly (3-hydroxybutyrate) microspheres

D Ahmed, H Puthussery, P Basnett… - International Journal of …, 2021 - mdpi.com
This study deals with the process of optimization and synthesis of Poly (3-hydroxybutyrate)
microspheres with encapsulated Cl-amidine. Cl-amidine is an inhibitor of peptidylarginine …

Characterization of polydioxanone in near-field electrospinning

W E. King III, Y Gillespie, K Gilbert, G L. Bowlin - Polymers, 2019 - mdpi.com
Electrospinning is a popular method for creating random, non-woven fibrous templates for
biomedical applications, and a subtype technique termed near-field electrospinning (NFES) …

Potential for Manuka honey‐inspired therapeutics to improve the host–biomaterial response

EN Main, GL Bowlin - MedComm–Biomaterials and …, 2022 - Wiley Online Library
Honey has been used by a wide variety of cultures across the world and for thousands of
years to prevent infection and improve wound healing. Recently, Manuka honey has been …