Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …

Multiple sclerosis (MS) is a chronic immune-mediated demyelinating disease of the central
nervous system characterized by relapses and remissions. The risk of acquiring this …

Historically, vitamin D has been associated with the regulation of bone metabolism.
However, increasing evidence demonstrates a strong association between vitamin D …

Vitamin D is a pleiotropic secosteroid hormone important for health and disease prevention.
The actions of vitamin D are mediated by the vitamin D receptor that binds the active form of …

Background Low serum vitamin D concentrations have been reported in several
autoimmune disorders. Objective To assess whether low serum vitamin D concentrations …

Epidemiological studies have shown that a poor vitamin D status is associated with an
increased risk of several diseases, including autoimmune diseases. The immune regulatory …

Autoimmune diseases cumulatively affect 5–10% of the industrial world population and are
a significant cause of morbidity and mortality. In recent decades rates are rising worldwide …

Vitamin D, a fat-soluble prohormone, is synthesised in response to sunlight. Vitamin D
requires two metabolic conversions, 25-hydroxylation in the liver and 1a-hydroxylation in the …

Vitamin D is synthesized from cholesterol in the skin (80–90%) under the sunlight and then
metabolized into an active D hormone in liver, kidney and peripheral immune/inflammatory …

Multiple sclerosis (MS) is the most common acquired inflammatory demyelinating disorder of
the central nervous system (CNS). Not unlike many inflammatory diseases with a presumed …