Recombination is a key molecular mechanism that has profound implications on both micro-
and macroevolutionary processes. However, the determinants of recombination rate …

Meiotic cells introduce numerous programmed DNA double-strand breaks (DSBs) into their
genome to stimulate crossover recombination. DSB numbers must be high enough to …

Myosin storage myopathy (MSM) is a rare skeletal muscle disorder caused by mutations in
the slow muscle/β-cardiac myosin heavy chain (MHC) gene. MSM missense mutations …

ORFanage is a system designed to assign open reading frames (ORFs) to known and novel
gene transcripts while maximizing similarity to annotated proteins. The primary intended use …

Gaining a better understanding of rates and patterns of meiotic recombination is crucial for
improving evolutionary genomic modelling, with applications ranging from demographic to …

Large, whole-genome sequencing (WGS) data sets containing families provide an important
opportunity to identify crossovers and shared genetic material in siblings. However, the high …

Human recombination maps are a valuable resource for association and linkage studies
and crucial for many inferences of population history and natural selection. Existing maps …

Biological relatedness is a key consideration in studies of behavior, population structure,
and trait evolution. Except for parent–offspring dyads, pedigrees capture relatedness …

Meiotic recombination landscapes differ greatly between distantly and closely related taxa,
populations, individuals, sexes, and even within genomes; however, the factors driving this …

Steady-state expression quantitative trait loci (eQTLs) explain only a fraction of disease-
associated loci identified through genome-wide association studies (GWASs), while eQTLs …