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The role of voltage-gated sodium channels in pain signaling
Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Innovations and advances in modelling and measuring pain in animals
Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …
decade as a result of technological advancements, the continued dearth of translational …
Emerging targets in photopharmacology
The field of photopharmacology uses molecular photoswitches to establish control over the
action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of …
action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of …
Breaking barriers to novel analgesic drug development
Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …
Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq–based resource for pain and sensory neuroscience research
2. Methods We performed RNA-seq for hDRG and integratively analyzed the transcriptome
by comparing it with publicly available human and mouse RNA-seq data sets (sources …
by comparing it with publicly available human and mouse RNA-seq data sets (sources …
[HTML][HTML] Toward a mechanism-based approach to pain diagnosis
The past few decades have witnessed a huge leap forward in our understanding of the
mechanistic underpinnings of pain, in normal states where it helps protect from injury, and …
mechanistic underpinnings of pain, in normal states where it helps protect from injury, and …
Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells
Human skin uses millions of hairs and glands distributed across the body surface to function
as an external barrier, thermoregulator and stimuli sensor. The large-scale generation of …
as an external barrier, thermoregulator and stimuli sensor. The large-scale generation of …
Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions
Human induced pluripotent stem cells (iPSC) hold promise for modeling diseases in
individual human genetic backgrounds and thus for develo** precision medicine. Here …
individual human genetic backgrounds and thus for develo** precision medicine. Here …
Composite pain biomarker signatures for objective assessment and effective treatment
Pain is a subjective sensory experience that can, mostly, be reported but cannot be directly
measured or quantified. Nevertheless, a suite of biomarkers related to mechanisms, neural …
measured or quantified. Nevertheless, a suite of biomarkers related to mechanisms, neural …
Pathogenesis of paclitaxel-induced peripheral neuropathy: A current review of in vitro and in vivo findings using rodent and human model systems
Abstract Paclitaxel (Brand name Taxol) is widely used in the treatment of common cancers
like breast, ovarian and lung cancer. Although highly effective in blocking tumor progression …
like breast, ovarian and lung cancer. Although highly effective in blocking tumor progression …