Gene therapy using nucleic acids has many clinical applications for the treatment of
diseases with a genetic origin as well as for the development of innovative vaccine …

Regardless of advances in detection and treatment, breast cancer affects about 1.5 million
women all over the world. Since the last decade, genome-wide association studies (GWAS) …

The p53 pathway is inactivated in the majority of human cancers. Although this perturbation
frequently occurs through the mutation or deletion of p53 itself, there are other mechanisms …

Abstract The miR-19 family (miR-19a and miR-19b-1) are key oncogenic components of the
miR-17-92 cluster. Overexpression of miR-19 is strongly associated with cancer invasion …

For several decades, p53 has been detected in cancer biopsies by virtue of its high protein
expression level which is considered indicative of mutation. Surprisingly, however, mouse …

All living beings are programmed to death due to aging and age-related processes. Aging is
a normal process of every living species. While all cells are inevitably progressing towards …

Background The hepatocellular carcinoma (HCC) incident rate is gradually increasing
yearly despite all the research and efforts taken by scientific communities and governing …

Aging is a normal process of living being. It has been reported that multiple cellular changes,
including oxidative damage/mitochondrial dysfunction, telomere shortening, inflammation …

Abstract Argonaute2 (AGO2) is an effector of small RNA mediated gene silencing.
Increasing evidence show that post-translational modifications of AGO2 can change miRNA …

Background Angiogenesis is a key process for tumor progression and a target for treatment.
However, the regulation of breast cancer angiogenesis and its relevance for clinical …