The MYC proto-oncogene has been implicated in the pathogenesis of most types of human
tumors. MYC activation alone in many normal cells is restrained from causing tumorigenesis …

The MYC transcription factor, encoded by the c‐MYC proto‐oncogene, is activated by
growth‐promoting signals, and is a key regulator of biosynthetic and metabolic pathways …

Although the MYC oncogene has been implicated in cancer, a systematic assessment of
alterations of MYC, related transcription factors, and co-regulatory proteins, forming the …

Cellular senescence is associated with ageing and cancer in vivo and has a proven tumour-
suppressive function. Common to both ageing and cancer is the generation of DNA damage …

Myc proteins regulate cell growth and division and are implicated in a wide range of human
cancers. We show here that Fbw7, a component of the SCFFbw7 ubiquitin ligase and a …

Myc genes are key regulators of cell proliferation, and their deregulation contributes to the
genesis of most human tumours. Recently, a wealth of data has shed new light on the …

Abstract The INK4b–ARF–INK4a locus encodes two members of the INK4 family of cyclin-
dependent kinase inhibitors, p15 INK4b and p16 INK4a, and a completely unrelated protein …

The combined activity of three transcription factors can reprogram adult cells into induced
pluripotent stem cells (iPSCs). However, the transgenic methods used for delivering …

Generating pluripotent stem cells directly from cells obtained from patients is one of the
ultimate goals in regenerative medicine. Two" reprogramming" strategies for the generation …

The c-Myc proto-oncogene encodes a transcription factor that is essential for cell growth and
proliferation and is broadly implicated in tumorigenesis. However, the biological functions …