[HTML][HTML] Hsp70 negatively regulates autophagy via governing AMPK activation, and dual hsp70-autophagy inhibition induces synergetic cell death in NSCLC cells
Proteostasis mechanisms, such as proteotoxic-stress response and autophagy, are
increasingly recognized for their roles in influencing various cancer hallmarks such as …
increasingly recognized for their roles in influencing various cancer hallmarks such as …
[HTML][HTML] Berbamine promotes ferroptosis of esophageal squamous cell carcinoma by facilitating USP51-mediated GPX4 ubiquitination and degradation
H Peng, YP He, Y Hu, S Sheng, M Maitiyasen… - Biomedicine & …, 2024 - Elsevier
Esophageal cancer ranks among the most prevalent malignant tumors globally. The
prognosis for esophageal squamous cell carcinoma remains poor, with a 5-year survival …
prognosis for esophageal squamous cell carcinoma remains poor, with a 5-year survival …
Comprehensive pan-cancer analysis indicates UCHL5 as a novel cancer biomarker and promotes cervical cancer progression through the Wnt signaling pathway
L Bao, Y Wu, Z Ren, Y Huang, Y Jiang, K Li, X Xu, Y Ye… - Biology Direct, 2024 - Springer
Background UCHL5 was initially recognized as a multifunctional molecule. While recent
research has highlighted its involvement in tumor malignant biological behaviors, its specific …
research has highlighted its involvement in tumor malignant biological behaviors, its specific …
A Molecular Signature of the Ubiquitin-Proteasome System for Forecasting Prognosis in Thyroid Carcinoma Patients
H Zeng, X Geng, H Wan, X Qu, S Tang… - Journal of …, 2024 - Taylor & Francis
Background The ubiquitin-proteasome system (UPS) is vital for protein quality control and its
dysregulation is linked to diseases, including cancer. Targeting the UPS is becoming a …
dysregulation is linked to diseases, including cancer. Targeting the UPS is becoming a …
[HTML][HTML] Prognostic Value of PSMB5 and Correlations with LC3II and Reactive Oxygen Species Levels in the Bone Marrow Mononuclear Cells of Bortezomib-Resistant …
E Plakoula, G Kalampounias, S Alexis… - Current Issues in …, 2025 - mdpi.com
Proteasome inhibitors (PIs) constitute the most common type of induction treatment for
multiple myeloma. Interactions between the proteasome, autophagy, and reactive oxygen …
multiple myeloma. Interactions between the proteasome, autophagy, and reactive oxygen …
Thiostrepton suppresses colorectal cancer progression through reactive oxygen species related endoplasmic reticulum stress
Z Li, J Nie, R Zhou, H Huang, X Li, L Wang, L Lv… - Toxicology and Applied …, 2025 - Elsevier
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide.
Due to the poor therapeutic efficacy of CRC treatments and poor prognosis of the disease …
Due to the poor therapeutic efficacy of CRC treatments and poor prognosis of the disease …
A novel defined risk signature of ferroptosis-related lncRNAs for predicting prognosis, immune infiltration, and chemotherapy response in multiple myeloma
W Yu, Z **g, J Tang, J Chen - Discover Oncology, 2025 - Springer
Background Ferroptosis, an iron-dependent form of programmed cell death, has been
implicated in various types of cancer. However, the association between ferroptosis-related …
implicated in various types of cancer. However, the association between ferroptosis-related …