A clear relationship between diabetes and cardiovascular disease has been established for
decades. Despite this, the mechanisms by which diabetes contributes to plaque formation …

Here we overview the role of reactive nitrogen species (nitrosative stress) and associated
pathways in the pathogenesis of diabetic vascular complications. Increased extracellular …

OBJECTIVE—Sulforaphane is an activator of transcription factor NF-E2–related factor-2
(nrf2) that regulates gene expression through the promoter antioxidant response element …

Scope High glycaemic sugars result in blood‐glucose spikes, while large doses of post‐
prandial fructose inundate the liver, causing an imbalance in energy metabolism, both …

Significance: Flavonoids can interact with multiple molecular targets to elicit their cellular
effects, leading to changes in signal transduction, gene expression, and/or metabolism …

The rates of formation of superoxide and hydrogen peroxide at different electron-donating
sites in isolated mitochondria are critically dependent on the substrates that are added …

Methylglyoxal (MGO) is a non-enzymatic metabolite in the glycolytic pathway and its
concentration in blood and tissues is elevated in diabetes and renal failure. MGO induces …

Aim High glucose-induced oxidative stress has been suggested as one of the mediators of
endothelial damage in diabetes. The major endothelial protein, endoglin, has been found …

The α-glucosidase inhibitor acarbose, which slows carbohydrate digestion and blunts
postprandial rises in plasma glucose, has long been used to treat patients with type 2 …

OBJECTIVE: Endothelial dysfunction is a key event in the onset and progression of
atherosclerosis associated with diabetes. Increasing cell senescence may lead to …