AlphaFold predicts novel human proteins with knots

AP Perlinska, WH Niemyska, BA Gren… - Protein …, 2023 - Wiley Online Library
The fact that proteins can have their chain formed in a knot is known for almost 30 years.
However, as they are not common, only a fraction of such proteins is available in the Protein …

Preliminary structure–activity relationship study of the MMV pathogen box compound MMV675968 (2, 4-diaminoquinazoline) unveils novel inhibitors of Trypanosoma …

D Dize, RB Tata, R Keumoe, RM Kouipou Toghueo… - Molecules, 2022 - mdpi.com
New drugs are urgently needed for the treatment of human African trypanosomiasis (HAT).
In line with our quest for novel inhibitors of trypanosomes, a small library of analogs of the …