A conceptual framework for astrocyte function

C Murphy-Royal, SN Ching, T Papouin - Nature neuroscience, 2023 - nature.com
The participation of astrocytes in brain computation was hypothesized in 1992, coinciding
with the discovery that these cells display a form of intracellular Ca2+ signaling sensitive to …

Making sense of astrocytic calcium signals—from acquisition to interpretation

A Semyanov, C Henneberger, A Agarwal - Nature Reviews …, 2020 - nature.com
Astrocytes functionally interact with neurons and with other brain cells. Although not
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …

Astrocytes regulate cortical state switching in vivo

KE Poskanzer, R Yuste - Proceedings of the National Academy of …, 2016 - pnas.org
The role of astrocytes in neuronal function has received increasing recognition, but
disagreement remains about their function at the circuit level. Here we use in vivo two …

Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain

H Monai, M Ohkura, M Tanaka, Y Oe, A Konno… - Nature …, 2016 - nature.com
Transcranical direct current stimulation (tDCS) is a treatment known to ameliorate various
neurological conditions and enhance memory and cognition in humans. tDCS has gained …

Interoception and the origin of feelings: A new synthesis

GB Carvalho, A Damasio - BioEssays, 2021 - Wiley Online Library
Feelings are conscious mental events that represent body states as they undergo
homeostatic regulation. Feelings depend on the interoceptive nervous system (INS), a …

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

J Wahis, A Baudon, F Althammer, D Kerspern… - Nature …, 2021 - nature.com
Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural
circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby …

Astrocytes modulate sensory-evoked neuronal network activity

J Lines, ED Martin, P Kofuji, J Aguilar… - Nature communications, 2020 - nature.com
While neurons principally mediate brain function, astrocytes are emerging as cells with
important neuromodulatory actions in brain physiology. In addition to homeostatic roles …

Septal cholinergic neuromodulation tunes the astrocyte-dependent gating of hippocampal NMDA receptors to wakefulness

T Papouin, JM Dunphy, M Tolman, KT Dineley… - Neuron, 2017 - cell.com
The activation of the N-methyl D-aspartate receptor (NMDAR) is controlled by a glutamate-
binding site and a distinct, independently regulated, co-agonist-binding site. In most brain …

Astrocytes: Orchestrating synaptic plasticity?

M De Pittà, N Brunel, A Volterra - Neuroscience, 2016 - Elsevier
Synaptic plasticity is the capacity of a preexisting connection between two neurons to
change in strength as a function of neural activity. Because synaptic plasticity is the major …

Do stars govern our actions? Astrocyte involvement in rodent behavior

JF Oliveira, VM Sardinha, S Guerra-Gomes… - Trends in …, 2015 - cell.com
Astrocytes have emerged as important partners of neurons in information processing.
Important progress has been made in the past two decades in understanding the role of …