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Progressive multiple sclerosis: from pathophysiology to therapeutic strategies
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that
involves demyelination and axonal degeneration. Although substantial progress has been …
involves demyelination and axonal degeneration. Although substantial progress has been …
Progressive multiple sclerosis: prospects for disease therapy, repair, and restoration of function
Multiple sclerosis is a major cause of neurological disability, which accrues predominantly
during progressive forms of the disease. Although development of multifocal inflammatory …
during progressive forms of the disease. Although development of multifocal inflammatory …
Optic neuritis
PURPOSE OF REVIEW This article discusses the clinical presentation, evaluation, and
management of the patient with optic neuritis. Initial emphasis is placed on clinical history …
management of the patient with optic neuritis. Initial emphasis is placed on clinical history …
Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial
Background The human monoclonal antibody opicinumab (BIIB033, anti-LINGO-1) has
shown remyelinating activity in preclinical studies. We therefore assessed the safety and …
shown remyelinating activity in preclinical studies. We therefore assessed the safety and …
Neuron-oligodendrocyte interactions in the structure and integrity of axons
The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction.
Oligodendrocytes and axons have a reciprocal signaling relationship in which …
Oligodendrocytes and axons have a reciprocal signaling relationship in which …
Assessing treatment outcomes in multiple sclerosis trials and in the clinical setting
Increasing numbers of drugs are being developed for the treatment of multiple sclerosis
(MS). Measurement of relevant outcomes is key for assessing the efficacy of new drugs in …
(MS). Measurement of relevant outcomes is key for assessing the efficacy of new drugs in …
Phenytoin–An anti-seizure drug: Overview of its chemistry, pharmacology and toxicology
Phenytoin is a long-standing, anti-seizure drug widely used in clinical practice. It has also
been evaluated in the context of many other illnesses in addition to its original epilepsy …
been evaluated in the context of many other illnesses in addition to its original epilepsy …
Leveraging visual outcome measures to advance therapy development in neuroimmunologic disorders
The visual system offers unparalleled precision in the assessment of neuroaxonal damage.
With the majority of patients with multiple sclerosis (MS) experiencing afferent and efferent …
With the majority of patients with multiple sclerosis (MS) experiencing afferent and efferent …
Multiple sclerosis pathogenesis and updates in targeted therapeutic approaches
Abstract Purpose of Review In this review, we provide a comprehensive update on current
scientific advances and emerging therapeutic approaches in the field of multiple sclerosis …
scientific advances and emerging therapeutic approaches in the field of multiple sclerosis …
Anti-inflammatory and neuroprotective agents in clinical trials for CNS disease and injury: where do we go from here?
Neurological disorders are major contributors to death and disability worldwide. The
pathology of injuries and disease processes includes a cascade of events that often involve …
pathology of injuries and disease processes includes a cascade of events that often involve …