The methoxy substituent is prevalent in natural products and, consequently, is present in
many natural product-derived drugs. It has also been installed in modern drug molecules …

Cell cycle regulation is performed by cyclins and cyclin dependent kinases (CDKs).
Recently, it has become clear that reactive oxygen species (ROS) influence the presence …

Abstract The Epidermal Growth Factor Receptor (EGFR) is frequently found to be mutated in
non-small cell lung cancer. Oncogenic EGFR has been successfully targeted by tyrosine …

GPX4 represents a promising yet difficult-to-drug therapeutic target for the treatment of,
among others, drug-resistant cancers. Although most GPX4 inhibitors rely on a …

The epidermal growth factor receptor (EGFR) family plays a critical role in vital cellular
processes and in various cancers. Known EGFR inhibitors exhibit distinct antitumor …

The epidermal growth factor receptor (EGFR) is historically the prototypical receptor tyrosine
kinase, being the first cloned and the first where the importance of ligand-induced dimer …

Covalent inhibition is an efficient molecular mechanism for inhibiting enzymes or modulating
the function of proteins and is found in the action of many drugs and biologically active …

Modern drug design aims to discover novel lead compounds with attractable chemical
profiles to enable further exploration of the intersection of chemical space and biological …

The sesquiterpene lactone class of natural products displays a diverse array of biological
activities due to the presence of the α-methylene-γ-lactone motif. However, clinical …

A new series of pyrazolo [3, 4-d] pyrimidine/triazine hybrids 6a-r was designed as antitumor
and anticonvulsant agents. All the prepared compounds were evaluated against colon (HCT …