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ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling
Stimulator of interferon genes (STING) is an intracellular sensor of cyclic di-nucleotides
involved in the innate immune response against pathogen-or self-derived DNA. STING …
involved in the innate immune response against pathogen-or self-derived DNA. STING …
Sensor sensibility—HIV-1 and the innate immune response
Innate immunity represents the human immune system's first line of defense against a
pathogenic intruder and is initiated by the recognition of conserved molecular structures …
pathogenic intruder and is initiated by the recognition of conserved molecular structures …
Myeloid cell interaction with HIV: a complex relationship
Cells of the myeloid lineage, particularly macrophages, serve as primary hosts for HIV in
vivo, along with CD4 T lymphocytes. Macrophages are present in virtually every tissue of the …
vivo, along with CD4 T lymphocytes. Macrophages are present in virtually every tissue of the …
Disrupting HIV‐1 capsid formation causes cGAS sensing of viral DNA
Detection of viral DNA by cyclic GMP‐AMP synthase (cGAS) is a first line of defence leading
to the production of type I interferon (IFN). As HIV‐1 replication is not a strong inducer of IFN …
to the production of type I interferon (IFN). As HIV‐1 replication is not a strong inducer of IFN …
Efferocytosis of pathogen-infected cells
The prompt and efficient clearance of unwanted and abnormal cells by phagocytes is termed
efferocytosis and is crucial for organism development, maintenance of tissue homeostasis …
efferocytosis and is crucial for organism development, maintenance of tissue homeostasis …
T cell-tropic HIV efficiently infects alveolar macrophages through contact with infected CD4+ T cells
Alveolar macrophages (AMs) are critical for defense against airborne pathogens and AM
dysfunction is thought to contribute to the increased burden of pulmonary infections …
dysfunction is thought to contribute to the increased burden of pulmonary infections …
Mechanism of interferon-stimulated gene induction in HIV-1-infected macrophages
Viruses manipulate the complex interferon and interferon-stimulated gene (ISG) system in
different ways. We have previously shown that HIV inhibits type I and III interferons in its key …
different ways. We have previously shown that HIV inhibits type I and III interferons in its key …
HIV-1-induced type I IFNs promote viral latency in macrophages
Macrophages chronically infected with HIV-1 serve as a reservoir that contributes to HIV-1
persistence during antiretroviral therapy; however, the mechanisms governing the …
persistence during antiretroviral therapy; however, the mechanisms governing the …
Cannabidiol modulates expression of type I IFN response genes and HIV infection in macrophages
Cannabis (Cannabis sativa) is a widely used drug in the United States and the frequency of
cannabis use is particularly high among people living with HIV (PLWH). One key component …
cannabis use is particularly high among people living with HIV (PLWH). One key component …
HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells
Chronic infection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV)
affects an estimated 35 million and 75 million individuals worldwide, respectively. These …
affects an estimated 35 million and 75 million individuals worldwide, respectively. These …