Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …
aging population worldwide. The enormous challenge which AD possesses to global …
Combination drug therapy for the management of Alzheimer's disease
Alzheimer's disease (AD) is the leading cause of dementia worldwide. Even though the
number of AD patients is rapidly growing, there is no effective treatment for this …
number of AD patients is rapidly growing, there is no effective treatment for this …
Current pharmacotherapy and multi-target approaches for Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by decreased
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …
Multi-target design strategies for the improved treatment of Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial syndrome resulting in profound misery and
poses a substantial burden on human health, economy, and society throughout the world …
poses a substantial burden on human health, economy, and society throughout the world …
Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
[HTML][HTML] Memantine: Updating a rare success story in pro-cognitive therapeutics
The great potential for NMDA receptor modulators as druggable targets in
neurodegenerative disorders has been met with limited success. Considered one of the rare …
neurodegenerative disorders has been met with limited success. Considered one of the rare …
[HTML][HTML] A molecular approach in drug development for Alzheimer's disease
An increase in dementia numbers and global trends in population aging across the world
prompts the need for new medications to treat the complex biological dysfunctions, such as …
prompts the need for new medications to treat the complex biological dysfunctions, such as …
From combinations to multitarget‐directed ligands: A continuum in Alzheimer's disease polypharmacology
C Albertini, A Salerno… - Medicinal Research …, 2021 - Wiley Online Library
The continued drug discovery failures in complex neurodegenerative diseases, including
Alzheimer's disease (AD), has raised questions about the classical paradigm “one‐drug …
Alzheimer's disease (AD), has raised questions about the classical paradigm “one‐drug …
Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …
available therapy is limited to the symptomatic treatment and its efficacy remains …
Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine
F Zemek, L Drtinova, E Nepovimova… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is a world-wide health problem with implications for
an increasing number of people and countries. Populations suffering from AD financially …
an increasing number of people and countries. Populations suffering from AD financially …