Since its discovery in 1983, the epigenetics of human cancer has been in the shadows of
human cancer genetics. But this area has become increasingly visible with a growing …

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the
United States with a median survival of< 6 mo and a dismal 5-yr survival rate of 3%–5%. The …

Pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year survival
rate of 4%. A key hallmark of PDAC is extensive stromal involvement, which makes …

To elucidate gene function on a global scale, we identified pairs of genes that are
coexpressed over 3182 DNA microarrays from humans, flies, worms, and yeast. We found …

Abstract microRNAs are functional, 22 nt, noncoding RNAs that negatively regulate gene
expression. Disturbance of microRNA expression may play a role in the initiation and …

Although at the genetic level cancer is caused by diverse mutations, epigenetic
modifications are characteristic of all cancers, from apparently normal precursor tissue to …

K-ras mutations occur frequently in epithelial cancers. Using short hairpin RNAs to deplete K-
Ras in lung and pancreatic cancer cell lines harboring K-ras mutations, two classes were …

Many studies have used DNA microarrays to identify the gene expression signatures of
human cancer, yet the critical features of these often unmanageably large signatures remain …

The host stromal response to an invasive epithelial carcinoma is frequently called a
desmoplastic reaction (DR) and is a universal feature of pancreatic ductal adenocarcinoma …

Background: The precise details of pancreatic ductal adenocarcinoma (PDAC)
pathogenesis are still insufficiently known, requiring the use of higthroughput methods …