Stem cell-based therapy for human diseases

DM Hoang, PT Pham, TQ Bach, ATL Ngo… - Signal transduction and …, 2022‏ - nature.com
Recent advancements in stem cell technology open a new door for patients suffering from
diseases and disorders that have yet to be treated. Stem cell-based therapy, including …

Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review

R Margiana, A Markov, AO Zekiy, MU Hamza… - Stem Cell Research & …, 2022‏ - Springer
The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide
consideration because of their immense potential for immunomodulation and their …

Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis

XN **ang, SY Zhu, HC He, X Yu, Y Xu… - Stem cell research & …, 2022‏ - Springer
Osteoarthritis, as a degenerative disease, is a common problem and results in high
socioeconomic costs and rates of disability. The most commonly affected joint is the knee …

Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?

E Mianehsaz, HR Mirzaei, M Mahjoubin-Tehran… - Stem cell research & …, 2019‏ - Springer
Degenerative disorders of joints, especially osteoarthritis (OA), result in persistent pain and
disability and high costs to society. Nevertheless, the molecular mechanisms of OA have not …

Bone marrow mesenchymal stromal cell treatment in patients with osteoarthritis results in overall improvement in pain and symptoms and reduces synovial …

J Chahal, A Gómez-Aristizábal… - Stem cells …, 2019‏ - academic.oup.com
Patients with late-stage Kellgren-Lawrence knee osteoarthritis received a single intra-
articular injection of 1, 10, or 50 million bone marrow mesenchymal stromal cells (BM-MSCs) …

Intra-articular mesenchymal stem cell injection for knee osteoarthritis: mechanisms and clinical evidence

P Wei, R Bao - International Journal of Molecular Sciences, 2022‏ - mdpi.com
Knee osteoarthritis presents higher incidences than other joints, with increased prevalence
during aging. It is a progressive process and may eventually lead to disability. Mesenchymal …

Clinical trials with mesenchymal stem cell therapies for osteoarthritis: challenges in the regeneration of articular cartilage

DC Carneiro, LT Araújo, GC Santos… - International Journal of …, 2023‏ - mdpi.com
Osteoarthritis (OA) is a whole-joint disease primarily characterized by the deterioration of
hyaline cartilage. Current treatments include microfracture and chondrocyte implantation as …

[HTML][HTML] Articular cartilage regeneration in osteoarthritis

L Roseti, G Desando, C Cavallo, M Petretta, B Grigolo - Cells, 2019‏ - mdpi.com
There has been considerable advancement over the last few years in the treatment of
osteoarthritis, common chronic disease and a major cause of disability in older adults. In this …

Efficacy and safety of platelet-rich plasma injections for the treatment of osteoarthritis: a systematic review and meta-analysis of randomized controlled trials

Y **ong, C Gong, X Peng, X Liu, X Su, X Tao… - Frontiers in …, 2023‏ - frontiersin.org
Background In recent years, platelet-rich plasma (PRP) injections for osteoarthritis (OA)
have been widely promoted in clinical practice, but their effectiveness is controversial …

[HTML][HTML] Mesenchymal stem cells in knee osteoarthritis treatment: a systematic review and meta-analysis

Y Song, J Zhang, H Xu, Z Lin, H Chang, W Liu… - Journal of orthopaedic …, 2020‏ - Elsevier
Objective Stem cells are considered to be one of the greatest potential treatments to cure
degenerative diseases. Stem cells injection for knee osteoarthritis is still a relatively new …