In the last decade, researchers have paid much attention to the role of noncoding RNA
molecules in human diseases. Among the most important of these molecules are LncRNAs …

A significant obstacle to treating cancer is multidrug resistance (MDR), which is the capacity
of cancerous cells to develop resistance to both traditional and cutting-edge …

Hypertrophic scar (HS) considerably affects the appearance and causes tissue dysfunction
in patients. The low bioavailability of 5-fluorouracil poses a challenge for HS treatment. Here …

Gastrointestinal malignancies are common digestive system tumor worldwide. Nucleoside
analogues have been widely used as anticancer drugs for the treatment of a variety of …

The delivery of chemotherapeutical drugs via nanomaterials has become a focus of
pharmaceutical research over several decades due to improved drug delivery to cancer …

Pyrimidine analogs are part of the first-line chemotherapy regimen for gastrointestinal
cancers. Trifluridine combined with tipiracil, a specific thymidine phosphorylase inhibitor, in …

Objective (s): Colorectal cancer is the second deadly cancer for men and women worldwide.
Depending on the pathological attributes of the tumor, there are numerous therapeutic …

ABSTRACT A promising approach to treat colorectal cancer (CRC) involves combining
chemotherapy, epigenetics, and gene therapy to combat drug resistance. Multifunctional …

Background/Objectives: MIR27A rs895819 polymorphism has emerged as a potential
additional pharmacogenomic marker of fluoropyrimidine response. Current evidence on its …

fluorouracil is an essential component of systemic chemotherapy for colon, breast, head,
and neck cancer patients. However, tumoral overexpression of the dihydropyrimidine …