Long non-coding RNAs (lncRNAs) have been found to perform various functions in a wide
variety of important biological processes. To make easier interpretation of lncRNA …

The role of RNA polymerase (Pol) III in eukaryotic transcription is commonly thought of as
being restricted to a small set of highly expressed, housekee** non–protein-coding (nc) …

One-step multiple gene disruption in the model organism Saccharomyces cerevisiae is a
highly useful tool for both basic and applied research, but it remains a challenge. Here, we …

DNA methylation was first described almost a century ago; however, the rules governing its
establishment and maintenance remain elusive. Here we present data demonstrating that …

The CRISPR/Cas has been recently shown to be a powerful genome-editing tool in a variety
of organisms. However, these studies are mainly focused on protein-coding genes. The …

For the many years, the central dogma of molecular biology has been that RNA functions
mainly as an informational intermediate between a DNA sequence and its encoded protein …

The past few years have revealed that the genomes of all studied eukaryotes are almost
entirely transcribed, generating an enormous number of non–protein-coding RNAs …

In the past two decades, advances in sequencing technology and analysis of the human and
mouse genome have led to the discovery of many non-protein-coding RNAs (ncRNAs) …

Non-protein-coding sequences increasingly dominate the genomes of multicellular
organisms as their complexity increases, in contrast to protein-coding genes, which remain …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …