Here, we discuss the principles of allosteric activating mutations, propagation downstream of
the signals that they prompt, and allosteric drugs, with examples from the Ras signaling …

Here we ask: What is productive signaling? How to define it, how to measure it, and most of
all, what are the parameters that determine it? Further, what determines the strength of …

Background The constant evolving and development of next-generation sequencing
techniques lead to high throughput data composed of datasets that include a large number …

Aberrant enhancer activation is a key mechanism driving oncogene expression in many
cancers. While much is known about the regulation of larger chromosome domains in …

Chronic infection with Hepatitis B Virus (HBV) is a major cause of liver-related morbidity and
mortality worldwide. HBV-DNA integration into the human genome is recognized as a …

Lymphoid neoplasms represent a heterogeneous group of disease entities and subtypes
with markedly different molecular and clinical features. Beyond genetic alterations, lymphoid …

Understanding the biological and clinical impact of copy number aberrations (CNAs) on the
development of precision therapies in cancer remains an unmet challenge. Genetic …

Multiple myeloma is a hematological malignancy arising from immunoglobulin-secreting
plasma cells. It remains poorly understood how chromatin rewiring of regulatory elements …

Despite recent advances in therapeutic treatments, multiple myeloma (MM) remains an
incurable malignancy. Epigenetic factors contribute to the initiation, progression, relapse …

In multiple myeloma, abnormal plasma cells establish oncogenic niches within the bone
marrow by engaging the NF-κB pathway to nurture their survival while they accumulate pro …