The molecular mechanisms of cellular insulin action have been the focus of much
investigation since the discovery of the hormone 100 years ago. Insulin action is impaired in …

In the wake of the worldwide increase in type-2 diabetes, a major focus of research is
understanding the signaling pathways impacting this disease. Insulin signaling regulates …

Cellular circular RNAs (circRNAs) are generated by head-to-tail splicing and are present in
all multicellular organisms studied so far. Recently, circRNAs have emerged as a large class …

Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes
of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver …

Monocytes participate critically in atherosclerosis. There are 2 major subsets expressing
different chemokine receptor patterns: CCR2+ CX3CR1+ Ly-6Chi and CCR2–CX3CR1++ …

Physiologically important cell-signalling networks are complex, and contain several points of
regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the …

The heart is adapted to utilize all classes of substrates to meet the high-energy demand, and
it tightly regulates its substrate utilization in response to environmental changes. Although …

Obesity-induced chronic inflammation is a key component in the pathogenesis of insulin
resistance and the Metabolic syndrome. In this review, we focus on the interconnection …

Although a full understanding of insulin/insulin-like growth factor (IGF) action is evolving, the
discovery of insulin receptor substrate (IRS) proteins and their role to link cell surface …