AlphaFold has burst into our lives. A powerful algorithm that underscores the strength of
biological sequence data and artificial intelligence (AI). AlphaFold has appended projects …

The sequence-structure-function paradigm has dominated twentieth century molecular
biology. The paradigm tacitly stipulated that for each sequence there exists a single, well …

Catalysis enables many aspects of modern life, including fuels, products, plastics, and
medicines. Recent advances in catalysis have enabled us to realize higher efficiencies and …

The concept of allostery has become a central tenet in the study of biological systems. In
parallel, the discovery of allosteric drugs is generating new opportunities to selectively …

Cyclin-dependent kinases (CDKs), particularly CDK4 and CDK2, are crucial for cell cycle
progression from the Gap 1 (G1) to the Synthesis (S) phase by phosphorylating targets such …

Focusing on an important biomedical implication of allostery–design of allosteric drugs, we
describe characteristics of allosteric sites, effectors, and their modes of actions …

Small molecule molecular glues can nucleate protein complexes and rewire interactomes.
Molecular glues are widely used as probes for understanding functional proximity at a …

Traditionally, drugs are monovalent, targeting only one site on the protein surface. This
includes orthosteric and allosteric drugs, which bind the protein at orthosteric and allosteric …

Driver mutations can contribute to the initial processes of cancer, and their identification is
crucial for understanding tumorigenesis as well as for molecular drug discovery and …

Proteins interact with other proteins, with nucleic acids, lipids, carbohydrates and various
small molecules in the living cell. These interactions have been quantified and structurally …