Meningeal lymphatic vessels (mLVs), the functional lymphatic system present in the
meninges, are the key drainage route responsible for the clearance of molecules, immune …

Meningeal immunity refers to immune surveillance and immune defense in the meningeal
immune compartment, which depends on the unique position, structural composition of the …

Background: While drainage/removal of fluid and toxins from the brain by cerebrospinal fluid
(CSF) directly into venous blood is well-known, a second drainage route has recently been …

Background Alzheimer's disease (AD) is a progressive neurodegenerative disease
characterized by memory impairment. Previous studies have largely focused on alterations …

A primary purpose of sleep for humans is to remove toxins and metabolic wastes from the
brain (eg, Aβ, tau, lactate) that would otherwise build up and compromise brain functionality …

The adult human brain represents only 2% of the body's total weight, however it is one of the
most metabolically active organs in the mammalian body. Its high metabolic activity …

Systemic chemotherapeutics target cancer cells but are also known to impact other cells
away from the tumor. Questions remain whether systemic chemotherapy crosses the blood …

Background The meningeal lymphatic (mLym) system is a route for waste clearance from the
brain to the periphery that has been implicated in the pathogenesis of Alzheimer's disease …

For long the CNS had been considered to lack lymphatics. The last few years have been
spotted with works conflicting the immune-privilege status of CNS. Experimental evidence …

In 2015, meningeal lymphatic vessels (mLVs) were (re) discovered in mice and human dura
specimens. Two years later, the first report was published showing that mLVs can be …