Androgen deprivation therapy (ADT) and androgen receptor (AR)-targeted therapy are the
gold standard options for treating prostate cancer (PCa). These are initially effective, as …

Prostate cancer is a major cause of cancer morbidity and mortality. Intra-prostatic
inflammation is a risk factor for prostate carcinogenesis, with diet, chemical injury and an …

Deletion of the gene encoding the chromatin remodeler CHD1 is among the most common
alterations in prostate cancer (PCa); however, the tumor-suppressive functions of CHD1 and …

Simple Summary Prostate cancer can develop under hormone treatment and chemotherapy
from a castration-sensitive towards a castration-resistant into a drug resistant-tumor. The …

The discovery that androgens play an important role in the progression of prostate cancer
led to the development of androgen deprivation therapy (ADT) as a first line of treatment …

The discovery of the benefits of castration for prostate cancer treatment in 1941 led to
androgen deprivation therapy, which remains a mainstay of the treatment of men with …

Abstract Background Prostate cancer (PCa) is an age-related malignancy in men with a high
incidence rate. PCa treatments face many obstacles due to cancer cell resistance and many …

Androgenetic alopecia (AGA) is the most common type of hair loss and features progressive
miniaturization of hair follicles. Generally, the occurrence of AGA has long been thought to …

Background The cellular effects of androgen are transduced through the androgen receptor,
which controls the expression of genes that regulate biosynthetic processes, cell growth …

Intrinsically disordered proteins (IDPs) that lack a unique 3D structure and comprise a large
fraction of the human proteome play important roles in numerous cellular functions. Prostate …