Poly (ADP‐ribosyl) ation is an immediate DNA‐damage‐dependent post‐translational
modification of histones and other nuclear proteins that contributes to the survival of injured …

Poly-ADP-ribose polymerase-1 (PARP-1)'s multiple roles in the cell span from maintaining
life to inducing death. The processes PARP-1 is involved in include, but are not limited to …

Apoptosis-inducing factor (AIF), a mitochondrial oxidoreductase, is released into the
cytoplasm to induce cell death in response to poly (ADP-ribose)(PAR) polymerase-1 (PARP …

Perinatal hypoxic‐ischemic encephalopathy (HIE) is a significant cause of mortality and
morbidity in infants and young children. Therapeutic opportunities are very limited for …

It is now clear that apoptosis does not constitute the sole genetically encoded form of cell
death. Rather, cells can spontaneously undertake or exogenously be driven into a cell death …

The immature brain has long been considered to be resistant to the damaging effects of
hypoxia and hypoxia–ischemia (H/I). However, it is now appreciated that there are specific …

Caspase activation has been frequently viewed as synonymous with apoptotic cell death;
however, caspases can also contribute to processes that do not culminate in cell demise …

The major challenge in treating cancer is that many tumor cells carry mutations in key
apoptotic genes such as p53, Bcl family proteins or those affecting caspase signaling. Such …

Abstract Poly (ADP-ribosyl) ation (PARylation) is a reversible protein modification carried out
by the concerted actions of poly (ADP-ribose) polymerase (PARP) enzymes and poly (ADP …

Different cell-death mechanisms control many physiological and pathological processes in
humans. Mitochondria play important roles in cell death through the release of pro-apoptotic …