Peptide nucleic acid or PNA is a synthetic DNA mimic that contains a sequence of
nucleobases attached to a peptide-like backbone derived from N-2-aminoethylglycine. The …

Gene-editing technologies have revolutionized biotechnology, but current gene editors
suffer from several limitations. Here, we harnessed the power of gamma-modified peptide …

Nanopores have emerged as a prominent single‐molecule analytic tool with particular
promise for genomic applications. In this review, we discuss two potential applications of the …

We present an approach for fluorescent in situ detection of short, single-copy sequences
within genomic DNA in human cells. The single-copy sensitivity and single-base specificity …

Peptide nucleic acids (PNAs) are polyamide analogues of nucleic acids, very effective in
terms of affinity and selectivity in DNA/RNA recognition. As other supramolecular entities, the …

Comprehensive Summary Single‐nucleotide variants (SNVs) are crucial in disease
development, but their accurate detection is challenging due to their low abundance and …

Mutations in mitochondrial DNA (mtDNA) have been an essential cause of numerous
diseases, making their identification critically important. The majority of mtDNA screening …

Recent studies have shown that guanine‐rich (G‐rich) sequences with the potential to form
quadruplexes might play a role in normal transcription as well as overexpression of …

0* C (C (C)= O) N (CCNC) C (= O) CC. CCC (= O) N (CC (C)= O) C1CCCCC1NC. CCC (= O)
N (CCC (C) O) CNC. CCC (= O) N (CCNC) CC (C)= O. CCC (= O) N (CCNC) C [P@@](C) …

Cancer contributes to the most dreaded global disease, and collective types of cancer have
been identified as the second largest cause of death in the United States. The high mortality …