Oxidative cell death in cancer: Mechanisms and therapeutic opportunities

X An, W Yu, J Liu, D Tang, L Yang, X Chen - Cell Death & Disease, 2024 - nature.com
Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated
as natural byproducts during cellular processes, including metabolism. Under normal …

Role of mitochondrial alterations in human cancer progression and cancer immunity

SF Wang, LM Tseng, HC Lee - Journal of biomedical science, 2023 - Springer
Dysregulating cellular metabolism is one of the emerging cancer hallmarks. Mitochondria
are essential organelles responsible for numerous physiologic processes, such as energy …

Advancements in redox-sensitive micelles as nanotheranostics: a new horizon in cancer management

A Sikder, G Vambhurkar, E Amulya… - Journal of Controlled …, 2022 - Elsevier
Abstract World Health Organisation (WHO) delineated cancer as one of the foremost
reasons for mortality with 10 million deaths in the year 2020. Early diagnosis and effective …

Mitochondrial properties in skeletal muscle fiber

H Dong, SY Tsai - Cells, 2023 - mdpi.com
Mitochondria are the primary source of energy production and are implicated in a wide
range of biological processes in most eukaryotic cells. Skeletal muscle heavily relies on …

Mitochondria-derived H2O2 triggers liver regeneration via FoxO3a signaling pathway after partial hepatectomy in mice

H Bai, CW Fang, Y Shi, S Zhai, A Jiang, YN Li… - Cell Death & …, 2023 - nature.com
Reactive oxygen species (ROS) can induce oxidative injury and are generally regarded as
toxic byproducts, although they are increasingly recognized for their signaling functions …

[HTML][HTML] Liver and pancreatic toxicity of endocrine-disruptive chemicals: focus on mitochondrial dysfunction and oxidative stress

AV Lința, BM Lolescu, CA Ilie, M Vlad… - International Journal of …, 2024 - mdpi.com
In recent years, the worldwide epidemic of metabolic diseases, namely obesity, metabolic
syndrome, diabetes and metabolic-associated fatty liver disease (MAFLD) has been strongly …

Autophagy and apoptosis in acute brain injuries: from mechanism to treatment

C He, Y Xu, J Sun, L Li, JH Zhang… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Autophagy and apoptosis are two important cellular mechanisms behind brain
injuries, which are severe clinical situations with increasing incidences worldwide. To …

Single-atom manganese anchored on carbon dots for promoting mitochondrial targeting and photodynamic effect in cancer treatment

S Wang, M Ma, Q Liang, X Wu, K Abbas… - ACS Applied Nano …, 2022 - ACS Publications
The sustained rapid growth of tumor cells depends directly on the activity of mitochondria,
which are important targets for many cancer drugs. Here, we report on a self-targeting …

[HTML][HTML] The rare-earth yttrium induces cell apoptosis and autophagy in the male reproductive system through ROS-Ca2+-CamkII/Ampk axis

F Hou, J Huang, F Qing, T Guo, S Ouyang, L **e… - Ecotoxicology and …, 2023 - Elsevier
China has the world's largest reserves of rare earth elements (REEs), but widespread
mining and application of REEs has led to an increased risk of potential pollution. Yttrium …

Targeted mito-and cardioprotection by malonate

R Schulz, G Heusch - Circulation Research, 2022 - Am Heart Assoc
Following the identification of the ischemic conditioning paradigm, numerous mechanical
and pharmacological interventions have been demonstrated to reduce infarct size in a …