The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …

Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …

Neuropathic pain is a pathological condition induced by a lesion or disease affecting the
somatosensory system, with symptoms like allodynia and hyperalgesia. It has a multifaceted …

Neurotransmitters (NTs) are biologically active chemicals, which mediate the
electrochemical transmission between neurons. NTs control numerous organic functions …

Human epidemiological studies suggest that chronic pain can increase mortality risk. We
investigated whether this was true in mice so that underlying mechanisms might be …

Abstract Alzheimer's disease (AD), the main cause of dementia worldwide, is characterized
by a complex and multifactorial etiology. In large part, excitatory neurotransmission in the …

Neurological dysfunctions are the most impactful and persistent consequences of traumatic
brain injury (TBI). Indeed, previous reports suggest that an association between TBI and …

The mechanisms underlying neuropathic pain are poorly understood. Here we show the
unexplored role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in 2 models of …

Improved living conditions have induced an increase of lifespan often accompanied by
comorbidities, responsible for pain, and by cognitive impairment and dementia, impairing …

Rodent models have been fundamental to understand chronic pain (CP) pathophysiology
and to test for potential treatments. Pain assessment in CP models is most frequently based …