Exosome processing and characterization approaches for research and technology development

JJ Lai, ZL Chau, SY Chen, JJ Hill… - Advanced …, 2022‏ - Wiley Online Library
Exosomes are extracellular vesicles that share components of their parent cells and are
attractive in biotechnology and biomedical research as potential disease biomarkers as well …

[HTML][HTML] Plant-derived exosome-like nanoparticles and their therapeutic activities

J Kim, S Li, S Zhang, J Wang - Asian journal of pharmaceutical sciences, 2022‏ - Elsevier
Nanotechnologies have been successfully applied to the treatment of various diseases.
Plant-derived exosome-like nanoparticles (PENs) are expected to become effective …

Extracellular vesicles in the pathogenesis and treatment of acute lung injury

Q Hu, S Zhang, Y Yang, JQ Yao, WF Tang… - Military Medical …, 2022‏ - Springer
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common life-
threatening lung diseases associated with acute and severe inflammation. Both have high …

Biodistribution of exosomes and engineering strategies for targeted delivery of therapeutic exosomes

H Choi, Y Choi, HY Yim, A Mirzaaghasi, JK Yoo… - Tissue engineering and …, 2021‏ - Springer
Exosomes are cell-secreted nano-sized vesicles which deliver diverse biological molecules
for intercellular communication. Due to their therapeutic potential, exosomes have been …

[HTML][HTML] Programming assembly of biomimetic exosomes: an emerging theranostic nanomedicine platform

X Xu, L Xu, C Wen, J **a, Y Zhang, Y Liang - Materials Today Bio, 2023‏ - Elsevier
Exosomes have emerged as a promising cell-free therapeutic approach. However,
challenges in large-scale production, quality control, and heterogeneity must be overcome …

[HTML][HTML] Exosomes in the diagnosis and treatment of renal cell cancer

S Boussios, P Devo, ICA Goodall, K Sirlantzis… - International Journal of …, 2023‏ - mdpi.com
Renal cell carcinoma (RCC) is the most prevalent type of kidney cancer originating from
renal tubular epithelial cells, with clear cell RCC comprising approximately 80% of cases …

Insights into exosome transport through the blood–brain barrier and the potential therapeutical applications in brain diseases

M Abdelsalam, M Ahmed, Z Osaid, R Hamoudi… - Pharmaceuticals, 2023‏ - mdpi.com
Drug delivery to the central nervous system (CNS) is limited due to the presence of the blood–
brain barrier (BBB), a selective physiological barrier located at the brain microvessels that …

[HTML][HTML] Exosome as drug delivery system: Current advancements

V Sharma, CD Mukhopadhyay - Extracellular Vesicle, 2024‏ - Elsevier
Exosomes are nanovesicles released from cells due to pathophysiological events. These
nanoparticles are resistant to metabolic destruction and can transcend the blood-brain …

[HTML][HTML] Clinical applications of exosomes: a critical review

KWA Lee, LKW Chan, LC Hung, LKW Phoebe… - International journal of …, 2024‏ - mdpi.com
Exosomes, small membrane-bound vesicles secreted by cells, have gained significant
attention for their therapeutic potential. Measuring 30–100 nm in diameter and derived from …

Polo-like kinase 1 inhibitors in human cancer therapy: development and therapeutic potential

J Zhang, L Zhang, J Wang, L Ouyang… - Journal of Medicinal …, 2022‏ - ACS Publications
Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …